This is story of a nurse "Sunita" who belongs to a poor family who works in a community health center taking care of COVID patients. One day Prime Minister of India - Shri Narendra Modi announces the compensation of 50 lacs for the doctors and nurses, who die due to COVID, while treating the COVID patients. Sunita thinks if she will get infected from COVID and die then after her death her family can get 50 lacs. The story "Ek thi Nurse" revolves around, Sunita and her struggle, will she get infected with the virus or not? Will her family be compensated or not?'